Bioorganic Chemistry paper on carbamoyl fluoride inhibitors published

Our latest publication “Carbamoyl fluorides as serine hydrolase inhibitors: a case study on FphI from Staphylococcus aureus.” is now online at 10.1016/j.bioorg.2026.109834

Exactly two years from cold email contact to joint publication between Otago and University of Ljubljana

First Email Wednesday, April 3, 2024 & published: Available online 3 April 2026

The group at Ljubljana is developing a new class of serine hydrolase inhibitors based on a carbamoyl fluoride warhead and we were working on the perfect test enzyme to demonstrate their potential in FphI from S. aureus. Driven by George Randall and Anže Meden who share first authorship it all came together quickly and very well. Also a big thank you to all the other involved co-authors. We are looking forward to expanding the collaborations in this area to many other projects.