Examples of crystals and high resolution datasets for FphE, F, H and I
Supervisor: Dr. Fellner (Biochemistry)
The Fph projects are in collaboration with the following international laboratories, interactions and visits to these laboratories are options for these projects:
Bogyo Lab – Stanford University – USA
Lentz Lab – University of Tromsø – Norway
Summary: This project is ideal if you want to use protein crystallography to study small molecule ligand binding at the atomic scale. Together with international collaborators (see collaborators page) we are discovering ligands and inhibitors that bind to these serine hydrolases. To develop these molecules into tools for the clinic (for imaging or drugging) we need to study them at the atomic level. This is where you come in – building on our established protocols to produce high quality crystals of one of these proteins (FphE, FphF, FphH or FphI) you will learn how to create protein crystals and determine the structure of the protein that forms it in complex with a wide range of ligands. This project also includes measurements at the Melbourne Australian synchrotron (in person or remotely depending on your preference). In addition, you will learn to use several other biochemical techniques to characterise the structure and function of your purified proteins. A student project will focus on 1-3 Fphs depending on degree level.
