Kārlis, Peter, Sara and Keith recently published a paper entitled “Nondestructive Spatial Dehydration Analysis of Crystalline Hydrates in Pharmaceutical Solid Dosage Forms Using Spatially Offset Low-Frequency Raman Spectroscopy” in Crystal Growth and Design (2022) 22 2946–2953 https://doi.org/10.1021/acs.cgd.1c01401.
The paper showcases the capabilities of Spatially Offset Low-Frequency Raman Spectroscopy (SOLFRS) in being able to examine subsurface layers in a tablet and observe dehydration of those subsurface layers. The spectra were analyzed using multivariate methods and mode assignments were provided via periodic boundary condition calculations. An interesting potential for examining tablet degradation without the need to split open the tablet or even remove it from its packaging.
