Pluymaekers NA, Dudink EA, Luermans JG, Meeder JG, Lenderink T, Widdershoven J, Bucx JJ, Rienstra M, Kamp O, Van Opstal JM, Alings M. Early or delayed cardioversion in recent-onset atrial fibrillation. New England Journal of Medicine. 2019 Apr 18;380(16):1499–508.
This paper review was found lost in my flawless organisational system. Apologies to Matilda(!) who provided the commentary.
This paper was mentioned in yesterday’s post.
Symptomatic patients with their first episode or recurrence of AF often present to hospital. Traditionally cardioversion has been carried out early, either chemically or electrically. However, it is known that many of these patients will spontaneously cardiovert within a 48 hour window. The authors of this Danish study sought to determine if delaying cardioversion, to that 48 hour mark, was non-inferior to early cardioversion when measuring rates of sinus rhythm at 4 week and in doing so avoiding many unnecessary medical interventions.
This was a multi-centre, randomized, open-label, non-inferiority study carried out across 15 urban hospitals in the Netherlands. Eligible patients were aged over 18, presenting with symptomatic, hemodynamically stable AF of less than 36 hours duration. This could be the first or a recurrent episode of AF. Patients who met inclusion criteria were randomly assigned to a ‘wait-and-see’ approach with delayed cardioversion at 48 hours, or early cardioversion during the initial admission. The primary end-point was sinus rhythm at 4 weeks. Secondary endpoints included cardiovascular events (CVA, TIA, ACS), ED presentations and time of index visit.
Patients in the ‘delayed’ group were administered rate control medication (mostly beta blockers) and discharged home once deemed stable. They were then reviewed as close as possible to 48 hours after symptoms onset. If at that point they were still in AF cardioversion took place. Anti-coagulation was continued in patients already on it and initiated in those with a CHADsVASC of 2.
437 patients were enrolled in the study and the two groups were comparable. Of the 218 in the delayed group 69% spontaneously cardioverted by 48 hours, 29% were cardioverted. Of the 219 in the early group 16% spontaneously cardioverted before treatment could be administered and 78% were cardioverted (83 pharmacologically and 88 electrically). Flecainide was the predominant drug of choice.
At 4 weeks 91% of the delayed group were in sinus, and 94% of the early cardioversion group. This met statistical criteria for non-inferiority. Cardiovascular complications were similar between the two groups. Of note the study was not powered to assess safety.
This study adds weight to the ‘wait-and-see’ approach to AF. It is particularly relevant to Rural Hospital practice as it is often impractical and unsafe to cardiovert patients due to staffing, resourcing and clinician experience, especially after hours. It does provide for more ‘wiggle’ room and potentially avoid unnecessary intervention. The counter argument is that you are encroaching in to the time that risk of an embolic event begins to rise. Guidelines have previously been that risk of an embolic CVA significantly increase after 48 hours from AF onset. However, there is growing concern this time window may be too generous, with embolic risks starting to increase at as little as 12 hours after onset.1
This trial also begs the question – what would happen if you waited 4 weeks before doing cardioversion in this cohort of stable patients?
At our recent inaugural Rural CME webinar Cardiologist, Dr Gerry Wilkins, advocated for the rate control +/- anti-coagulation with delayed or nil intervention approach. In his words:
“Calm down, give a decent oral dose of some rate slowing med, NOAC and discharge. In this era it is very rare I would consider immediate cardioversion.”
Matilda is a rural doctor in Taupō. She is the CME convener and the convener of GENA728 Cardiorespiratory medicine in rural hospitals.
Patients with recent-onset atrial fibrillation commonly undergo immediate restoration of sinus rhythm by pharmacologic or electrical cardioversion. However, whether immediate restoration of sinus rhythm is necessary is not known, since atrial fibrillation often terminates spontaneously.
In a multicenter, randomized, open-label, noninferiority trial, we randomly assigned patients with hemodynamically stable, recent-onset (<36 hours), symptomatic atrial fibrillation in the emergency department to be treated with a wait-and-see approach (delayed-cardioversion group) or early cardioversion. The wait-and-see approach involved initial treatment with rate-control medication only and delayed cardioversion if the atrial fibrillation did not resolve within 48 hours. The primary end point was the presence of sinus rhythm at 4 weeks. Noninferiority would be shown if the lower limit of the 95% confidence interval for the between-group difference in the primary end point in percentage points was more than −10.
The presence of sinus rhythm at 4 weeks occurred in 193 of 212 patients (91%) in the delayed-cardioversion group and in 202 of 215 (94%) in the early-cardioversion group (between-group difference, −2.9 percentage points; 95% confidence interval [CI], −8.2 to 2.2; P=0.005 for noninferiority). In the delayed-cardioversion group, conversion to sinus rhythm within 48 hours occurred spontaneously in 150 of 218 patients (69%) and after delayed cardioversion in 61 patients (28%). In the early-cardioversion group, conversion to sinus rhythm occurred spontaneously before the initiation of cardioversion in 36 of 219 patients (16%) and after cardioversion in 171 patients (78%). Among the patients who completed remote monitoring during 4 weeks of follow-up, a recurrence of atrial fibrillation occurred in 49 of 164 patients (30%) in the delayed-cardioversion group and in 50 of 171 (29%) in the early-cardioversion group. Within 4 weeks after randomization, cardiovascular complications occurred in 10 patients and 8 patients, respectively.
In patients presenting to the emergency department with recent-onset, symptomatic atrial fibrillation, a wait-and-see approach was noninferior to early cardioversion in achieving a return to sinus rhythm at 4 weeks.
- Nuotio I, Hartikainen JEK, Grönberg T, Biancari F, Airaksinen KEJ. Time to Cardioversion for Acute Atrial Fibrillation and Thromboembolic Complications. JAMA. 2014;312(6):647–649. doi:10.1001/jama.2014.3824↩︎