{"id":18,"date":"2021-03-30T00:27:42","date_gmt":"2021-03-29T11:27:42","guid":{"rendered":"https:\/\/blogs.otago.ac.nz\/lab\/?page_id=18"},"modified":"2021-11-03T16:14:54","modified_gmt":"2021-11-03T03:14:54","slug":"research-interest","status":"publish","type":"page","link":"https:\/\/blogs.otago.ac.nz\/lab\/research-interest\/","title":{"rendered":"Visible light photoinitiating system"},"content":{"rendered":"<h1 style=\"text-align: center\">Visible light photoinitiating system<\/h1>\n<p>&nbsp;<\/p>\n<p>Light-based crosslinking system offers powerful physico-chemical and mechanical control over hydrogel microenvironment to better dictate cellular function. In our group, we have developed a visible light photoinitiating system (patented) that uses natural\/everyday light to facilitate crosslinking reactions of a number of chemistry. We specifically use the transition metal complex, Ruthenium as the photocatalysts, to initiate crosslinking of chain-growth, step-growth and di-tyrosine reactions. We found that the visible light photoinitiating system offers higher advantage over traditionally used UV-polymerisation system or enzymatic crosslinking systems. Please see some selected publications below:<\/p>\n<ol>\n<li>X Cui; BG Soliman; CR Alcala-Orozco; J Li; MAM Vis; M Santos; SG Wise; R Levato; J Malda; TBF Woodfield; J Rnjak-Kovacina*; KS Lim*. Rapid photo-crosslinking of silk hydrogels with high cell-density and enhanced shape fidelity. Advanced Healthcare Materials; 2020, 9, 1901667.\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/adhm.201901667\">doi: 10.1002\/adhm.201901667<\/a><\/li>\n<li>M Baptista; H Joukhdar; C Alcala-Orozco; K Lau; S Jiang; X Cui; S He; F Tang; C Heu; T Woodfield; KS Lim*; J Rnjak-Kovacina*. Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering. RSC Biomaterials Science, 2020, 8, 7093-7105.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33079079\/\">doi: 10.1039\/d0bm01010c<\/a><\/li>\n<li>KS Lim; BJ Klotz; GCJ Lindberg; FPW Melchels; GJ Hooper; J Malda; D Gawlitta; TBF Woodfield. Visible Light Crosslinking of Gelatin Hydrogels Offers an Enhanced Cell Microenvironment with Improved Light Penetration Depth. Macromolecular Bioscience; 2019, 6, e1900098.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31026127\/\">doi: 10.1002\/mabi.201900098<\/a><\/li>\n<li>KS Lim*; GCJ Brown*; BF Farugia; GJ Hooper; TBF Woodfield. 2017. Covalent Integration of Heparin into Gelatin-methacryloyl Hydrogels for Enhanced Chondrogenesis. Macromolecular Bioscience. 2017. 17, 1700158.<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mabi.201700158\">\u00a0doi: 10.1002\/mabi.201700158<\/a><\/li>\n<li>KS Lim; Y Ramaswamy; JJ Roberts; MH Alves; LA Poole-Warren; PJ Martens. Promoting Cell Survival and Proliferation in Degradable Poly(vinyl alcohol)-Tyramine hydrogels. Macromolecular Bioscience, 2015. 15(10) :p. 1423-1432.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26097045\/\">doi: 10.1002\/mabi.201500121\u00a0<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h1><\/h1>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Visible light photoinitiating system &nbsp; Light-based crosslinking system offers powerful physico-chemical and mechanical control over hydrogel microenvironment to better dictate cellular function. In our group, we have developed a visible light photoinitiating system (patented) that uses natural\/everyday light to facilitate [&hellip;]<\/p>\n","protected":false},"author":41654,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.otago.ac.nz\/lab\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.otago.ac.nz\/lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.otago.ac.nz\/lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.otago.ac.nz\/lab\/wp-json\/wp\/v2\/users\/41654"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.otago.ac.nz\/lab\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":0,"href":"https:\/\/blogs.otago.ac.nz\/lab\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.otago.ac.nz\/lab\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}