{"id":55,"date":"2020-11-16T17:20:52","date_gmt":"2020-11-16T04:20:52","guid":{"rendered":"https:\/\/blogs.otago.ac.nz\/keithgordon\/?page_id=55"},"modified":"2020-11-16T17:24:18","modified_gmt":"2020-11-16T04:24:18","slug":"dr-sara-j-fraser-miller","status":"publish","type":"page","link":"https:\/\/blogs.otago.ac.nz\/keithgordon\/dr-sara-j-fraser-miller\/","title":{"rendered":"Dr Sara J. Fraser-Miller"},"content":{"rendered":"

\"\"<\/a><\/p>\n

My research primarily explores the use of vibrational spectroscopy and chemometrics for qualitative, quantitative and classification based analysis of a wide range of materials and systems.<\/p>\n

Vibrational spectroscopic methods provide a molecular fingerprint of a samples composition and structure in a non-destructive manner. This molecular fingerprint can be probed with the aid of multivariate analysis methods to gain insight into the sample. I have been involved in the use of Raman and IR spectroscopy to explore pharmaceutics1-6<\/sup>, particularly from the perspective of solid state form analysis, using techniques such as low frequency Raman7-15<\/sup> (Otago) and CARS16-20<\/sup> (Helsinki). The non-destructive assessment of plant material21<\/sup> and studying the chemical changes associated with degradation of traditional M\u0101ori textiles22-24<\/sup> and methods of preservation is a particularly interesting application. Biological minerals25-29<\/sup> are another avenue of interest, with a highlight being the exploration of hypomineralization in teeth from a spectroscopic standpoint30-32<\/sup>. We have also used spectroscopic analysis to assess samples associated with NZ primary industries33-35<\/sup>. A range of other materials have also been explored36-38<\/sup>. More recently, my focus has been shifting to the use of spectroscopy for the diagnosis of gastrointestinal illnesses.<\/p>\n

Employment:
\n2017-present<\/strong> Research Fellow, Chemistry Department and Dodd-Walls Center, University of Otago
\n2015-2017<\/strong> Postdoctoral Researcher, Chemistry Department and Dodd-Walls Center, University of Otago
\n2014-2015<\/strong> Postdoctoral Researcher, Faculty of Pharmacy, Helsinki University<\/p>\n

Education:
\n2014<\/strong>\u00a0PhD Chemistry \u2013 University of Otago
\n2010<\/strong>\u00a0PGDipSci Chemistry \u2013 University of Otago
\n2009<\/strong>\u00a0BSc Chemistry \u2013 University of Otago<\/p>\n

Selected Publications:<\/p>\n

    \n
  1. Fraser, S.; Gordon, K., Raman spectroscopy in the study of pharmaceuticals: the problems and solutions to sub-sampling and data analysis, Eur. Pharm. Rev <\/em>2014,<\/strong> 19<\/em>, 3-8.<\/li>\n
  2. Fraser, S. J.; Oughton, J.; Batten, W. A.; Clark, A. S.; Schmierer, D. M.; Gordon, K. C.; Strachan, C. J., Simultaneous qualitative and quantitative analysis of counterfeit and unregistered medicines using Raman spectroscopy. Journal of Raman Spectroscopy <\/em>2013,<\/strong> 44<\/em> (8), 1172-1180.<\/li>\n
  3. Koskinen, A.-K.; Fraser-Miller, S. J.; B\u00f8tker, J. P.; Heljo, V. P.; Barnsley, J. E.; Gordon, K. C.; Strachan, C. J.; Juppo, A. M., Physical stability of freeze-dried isomalt diastereomer mixtures. Pharmaceutical research <\/em>2016,<\/strong> 33<\/em> (7), 1752-1768.<\/li>\n
  4. Rosenqvist, K.; Airaksinen, S.; Fraser, S. J.; Gordon, K. C.; Juppo, A. M., Interaction of bioactive glass with clodronate. International journal of pharmaceutics <\/em>2013,<\/strong> 452<\/em> (1-2), 102-107.<\/li>\n
  5. Smith, G. P.; McGoverin, C. M.; Fraser, S. J.; Gordon, K. C., Raman imaging of drug delivery systems. Advanced drug delivery reviews <\/em>2015,<\/strong> 89<\/em>, 21-41.<\/li>\n
  6. Walker, G.; Ro\u0308mann, P.; Poller, B.; Lo\u0308bmann, K.; Grohganz, H.; Rooney, J. S.; Huff, G. S.; Smith, G. P.; Rades, T.; Gordon, K. C.; Strachan, C. J.; Fraser-Miller, S. J., Probing pharmaceutical mixtures during milling: The potency of low-frequency Raman spectroscopy in identifying disorder. Molecular pharmaceutics <\/em>2017,<\/strong> 14<\/em> (12), 4675-4684.<\/li>\n
  7. Adhikari, B. R.; B\u0113rzi\u0146\u0161, K.; Fraser-Miller, S. J.; Gordon, K. C.; Das, S. C., Co-Amorphization of Kanamycin with Amino Acids Improves Aerosolization. Pharmaceutics <\/em>2020,<\/strong> 12<\/em> (8), 715.<\/li>\n
  8. B\u0113rzi\u0146\u0161, K.; Sales, R. E.; Barnsley, J. E.; Walker, G.; Fraser-Miller, S. J.; Gordon, K. C., Low-Wavenumber Raman Spectral Database of Pharmaceutical Excipients. Vibrational Spectroscopy <\/em>2020<\/strong>, 103021.<\/li>\n
  9. Berzins, K.; Sutton, J. J.; Fraser-Miller, S. J.; Rades, T.; Korter, T. M.; Gordon, K. C., Solving the Computational Puzzle: Towards a Pragmatic Pathway for Modeling Low-Energy Vibrational Modes of Pharmaceutical Crystals. Crystal Growth & Design <\/em>2020<\/strong>.<\/li>\n
  10. Be\u0305rzin\u0327s\u030c, K. r.; Fraser-Miller, S. J.; Rades, T.; Gordon, K. C., Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib. Molecular pharmaceutics <\/em>2019,<\/strong> 16<\/em> (8), 3678-3686.<\/li>\n
  11. Lipi\u00e4inen, T.; Fraser-Miller, S. J.; Gordon, K. C.; Strachan, C. J., Direct comparison of low-and mid-frequency Raman spectroscopy for quantitative solid-state pharmaceutical analysis. Journal of pharmaceutical and biomedical analysis <\/em>2018,<\/strong> 149<\/em>, 343-350.<\/li>\n
  12. Mah, P. T.; Fraser, S. J.; Reish, M. E.; Rades, T.; Gordon, K. C.; Strachan, C. J., Use of low-frequency Raman spectroscopy and chemometrics for the quantification of crystallinity in amorphous griseofulvin tablets. Vibrational Spectroscopy <\/em>2015,<\/strong> 77<\/em>, 10-16.<\/li>\n
  13. Ruggiero, M. T.; Sutton, J. J.; Fraser-Miller, S. J.; Zaczek, A. J.; Korter, T. M.; Gordon, K. C.; Zeitler, J. A., Revisiting the thermodynamic stability of indomethacin polymorphs with low-frequency vibrational spectroscopy and quantum mechanical simulations. Crystal Growth & Design <\/em>2018,<\/strong> 18<\/em> (11), 6513-6520.<\/li>\n
  14. Salim, M.; Fraser-Miller, S. J.; Be\u0305rzin\u0327s\u030c, K. r.; Sutton, J. J.; Ramirez, G.; Clulow, A. J.; Hawley, A.; Beilles, S. p.; Gordon, K. C.; Boyd, B. J., Low-Frequency Raman Scattering Spectroscopy as an Accessible Approach to Understand Drug Solubilization in Milk-Based Formulations during Digestion. Molecular pharmaceutics <\/em>2020,<\/strong> 17<\/em> (3), 885-899.<\/li>\n
  15. Salim, M.; Fraser-Miller, S. J.; Sutton, J. J.; Be\u0305rzin\u0327s\u030c, K. r.; Hawley, A.; Clulow, A. J.; Beilles, S. p.; Gordon, K. C.; Boyd, B. J., Application of Low-Frequency Raman Scattering Spectroscopy to Probe in Situ Drug Solubilization in Milk during Digestion. The journal of physical chemistry letters <\/em>2019,<\/strong> 10<\/em> (9), 2258-2263.<\/li>\n
  16. Novakovic, D.; Isoma\u0308ki, A.; Pleunis, B.; Fraser-Miller, S. J.; Peltonen, L.; Laaksonen, T.; Strachan, C. J., Understanding dissolution and crystallization with imaging: a surface point of view. Molecular pharmaceutics <\/em>2018,<\/strong> 15<\/em> (11), 5361-5373.<\/li>\n
  17. Novakovic, D.; Peltonen, L.; Isoma\u0308ki, A.; Fraser-Miller, S. J.; Nielsen, L. H.; Laaksonen, T.; Strachan, C. J., Surface stabilization and dissolution rate improvement of amorphous compacts with thin polymer coatings: can we have it all? Molecular pharmaceutics <\/em>2020,<\/strong> 17<\/em> (4), 1248-1260.<\/li>\n
  18. Novakovic, D.; Saarinen, J.; Rojalin, T.; Antikainen, O.; Fraser-Miller, S. J.; Laaksonen, T.; Peltonen, L.; Isoma\u0308ki, A.; Strachan, C. J., Multimodal nonlinear optical imaging for sensitive detection of multiple pharmaceutical solid-state forms and surface transformations. Analytical chemistry <\/em>2017,<\/strong> 89<\/em> (21), 11460-11467.<\/li>\n
  19. Saarinen, J.; G\u00fctter, F.; Lindman, M.; Agopov, M.; Fraser\u2010Miller, S. J.; Scherlie\u00df, R.; Jokitalo, E.; Santos, H. A.; Peltonen, L.; Isom\u00e4ki, A., Cell\u2010Nanoparticle Interactions at (Sub)\u2013Nanometer Resolution Analyzed by Electron Microscopy and Correlative Coherent Anti\u2010Stokes Raman Scattering. Biotechnology journal <\/em>2019,<\/strong> 14<\/em> (4), 1800413.<\/li>\n
  20. Saarinen, J.; S\u00f6zeri, E.; Fraser-Miller, S. J.; Peltonen, L.; Santos, H. A.; Isom\u00e4ki, A.; Strachan, C. J., Insights into Caco-2 cell culture structure using coherent anti-Stokes Raman scattering (CARS) microscopy. International journal of pharmaceutics <\/em>2017,<\/strong> 523<\/em> (1), 270-280.<\/li>\n
  21. Alonso\u2010Serra, J.; Safronov, O.; Lim, K. J.; Fraser\u2010Miller, S. J.; Blokhina, O. B.; Campilho, A.; Chong, S. L.; Fagerstedt, K.; Haavikko, R.; Helariutta, Y., Tissue\u2010specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark. New Phytologist <\/em>2019,<\/strong> 222<\/em> (4), 1816-1831.<\/li>\n
  22. Ford, B.; Hanton, L. R.; Lomax, B. A.; Lowe, B. J.; Gordon, K. C.; Fraser, S. J.; Smith, C. A.; Korsten, A. In Relating colour, chemical and physical characteristics of artificially light-aged New Zealand plant fibres<\/em>, Proceedings of the ICOM-CC 17th Triennial Conference. International Council of Museums, 2014.<\/li>\n
  23. Lowe, B. J.; Smith, C. A.; Fraser-Miller, S. J.; Paterson, R. A.; Daroux, F.; Ngarimu-Cameron, R.; Ford, B.; Gordon, K. C., Light-ageing characteristics of M\u0101ori textiles: Colour, strength and molecular change. Journal of Cultural Heritage <\/em>2017,<\/strong> 24<\/em>, 60-68.<\/li>\n
  24. Samanali, G.; Paasi, I.; Lowe, B.; Smith, C.; Fraser-Miller, S.; Gordon, K., Understanding consolidants on harakeke fibres using Raman microscopy: Implications for conservation. Journal of Cultural Heritage <\/em>2020<\/strong>.<\/li>\n
  25. Jansen van Vuuren, L.; Kieser, J. A.; Dickenson, M.; Gordon, K. C.; Fraser\u2010Miller, S. J., Chemical and mechanical properties of snake fangs. Journal of Raman Spectroscopy <\/em>2016,<\/strong> 47<\/em> (7), 787-795.<\/li>\n
  26. Loch, C.; Swain, M. V.; Fraser, S. J.; Gordon, K. C.; Kieser, J. A.; Fordyce, R. E., Elemental and chemical characterization of dolphin enamel and dentine using X-ray and Raman microanalyzes (Cetacea: Delphinoidea and Inioidea). Journal of structural biology <\/em>2014,<\/strong> 185<\/em> (1), 58-68.<\/li>\n
  27. Stringer, M. D.; Fraser, S.; Gordon, K. C.; Sharples, K.; Windsor, J. A., Gallstones in N ew Z ealand: composition, risk factors and ethnic differences. ANZ journal of surgery <\/em>2013,<\/strong> 83<\/em> (7-8), 575-580.<\/li>\n
  28. Thomas, D. B.; Hauber, M. E.; Hanley, D.; Waterhouse, G. I.; Fraser, S.; Gordon, K. C., Analysing avian eggshell pigments with Raman spectroscopy. Journal of Experimental Biology <\/em>2015,<\/strong> 218<\/em> (17), 2670-2674.<\/li>\n
  29. van Vuuren, L. J.; Loch, C.; Kieser, J. A.; Gordon, K. C.; Fraser, S. J., Structure and mechanical properties of normal and anomalous teeth in the sand tiger shark Carcharias taurus. Journal of Zoo and Aquarium Research <\/em>2015,<\/strong> 3<\/em> (2), 29-36.<\/li>\n
  30. B\u0113rzi\u0146\u0161, K.; Sutton, J. J.; Loch, C.; Beckett, D.; Wheeler, B. J.; Drummond, B. K.; Fraser\u2010Miller, S. J.; Gordon, K. C., Application of low\u2010wavenumber Raman spectroscopy to the analysis of human teeth. Journal of Raman Spectroscopy <\/em>2019,<\/strong> 50<\/em> (10), 1375-1387.<\/li>\n
  31. Fraser, S. J.; Natarajan, A. K.; Clark, A. S.; Drummond, B. K.; Gordon, K. C., A Raman spectroscopic study of teeth affected with molar\u2013incisor hypomineralisation. Journal of Raman Spectroscopy <\/em>2015,<\/strong> 46<\/em> (2), 202-210.<\/li>\n
  32. Natarajan, A. K.; Fraser, S. J.; Swain, M. V.; Drummond, B. K.; Gordon, K. C., Raman spectroscopic characterisation of resin-infiltrated hypomineralised enamel. Analytical and bioanalytical chemistry <\/em>2015,<\/strong> 407<\/em> (19), 5661-5671.<\/li>\n
  33. McIntyre, S. M.; Ma, Q.; Burritt, D. J.; Oey, I.; Gordon, K. C.; Fraser\u2010Miller, S. J., Vibrational spectroscopy and chemometrics for quantifying key bioactive components of various plum cultivars grown in New Zealand. Journal of Raman Spectroscopy<\/em>.<\/li>\n
  34. Tew, X. W.; Fraser-Miller, S. J.; Gordon, K. C.; Morison, K. R., A comparison between laboratory and industrial fouling of reverse osmosis membranes used to concentrate milk. Food and bioproducts processing <\/em>2019,<\/strong> 114<\/em>, 113-121.<\/li>\n
  35. Robert, C.; Fraser-Miller, S. J.; Jessep, W. T.; Bain, W. E.; Hicks, T. M.; Ward, J. F.; Craigie, C. R.; Loeffen, M.; Gordon, K. C., Rapid discrimination of intact beef, venison and lamb meat using Raman spectroscopy. Food Chemistry <\/em>2020<\/strong>, 128441.<\/li>\n
  36. Ma, H.; Lee, L.; Brooksby, P. A.; Brown, S. A.; Fraser, S. J.; Gordon, K. C.; Leroux, Y. R.; Hapiot, P.; Downard, A. J., Scanning tunneling and atomic force microscopy evidence for covalent and noncovalent interactions between aryl films and highly ordered pyrolytic graphite. The Journal of Physical Chemistry C <\/em>2014,<\/strong> 118<\/em> (11), 5820-5826.<\/li>\n
  37. Eastwood, A.; Oze, C.; Fraser, S.; Cole, J.; Gravley, D.; Chambefort, I.; Gordon, K., Application of Raman spectroscopy to distinguish adularia and sanidine in drill cuttings from the Ngatamariki Geothermal Field, New Zealand. New Zealand Journal of Geology and Geophysics <\/em>2015,<\/strong> 58<\/em> (1), 66-77.<\/li>\n
  38. Dimartino, S.; Savory, D. M.; Fraser-Miller, S. J.; Gordon, K. C.; McQuillan, A. J., Microscopic and infrared spectroscopic comparison of the underwater adhesives produced by germlings of the brown seaweed species Durvillaea antarctica and Hormosira banksii. Journal of The Royal Society Interface <\/em>2016,<\/strong> 13<\/em> (117), 20151083.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    My research primarily explores the use of vibrational spectroscopy and chemometrics for qualitative, quantitative and classification based analysis of a wide range of materials and systems. Vibrational spectroscopic methods provide a molecular fingerprint of a samples composition and structure in a non-destructive manner. This molecular fingerprint can be probed with the aid of multivariate analysis […]<\/p>\n","protected":false},"author":35380,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-55","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.otago.ac.nz\/keithgordon\/wp-json\/wp\/v2\/pages\/55","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.otago.ac.nz\/keithgordon\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.otago.ac.nz\/keithgordon\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.otago.ac.nz\/keithgordon\/wp-json\/wp\/v2\/users\/35380"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.otago.ac.nz\/keithgordon\/wp-json\/wp\/v2\/comments?post=55"}],"version-history":[{"count":0,"href":"https:\/\/blogs.otago.ac.nz\/keithgordon\/wp-json\/wp\/v2\/pages\/55\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.otago.ac.nz\/keithgordon\/wp-json\/wp\/v2\/media?parent=55"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}