Karlis, Sara, Keith and Thomas Rades (Copenhagen) recently published a paper in Analytical Chemistry (2022) 94, 8241 – 8248 https://doi.org/10.1021/acs.analchem.2c00371 (369) that describes how low frequency Raman may be used to sense mobility of molecules in the glassy state. By monitoring the shape of the low frequency Raman scattering in the Stokes and anti-Stokes regions. Not only is it possible to see the primary glass transition temperature, the so-called Tg or Tα, but it is also possible the Tβ transition which represents much more subtle local changes in microstructure.
Tβ is important because it appears to be linked to shelf-life for pharmaceuticals.
