Congratulations to Antony Braithwaite and colleagues for gaining funding from the Health Research Council of New Zealand to study the role of p53 isoforms in cancer. Co-investigators on the grant are Noelyn Hung, Aaron Jeffs and Tania Slatter, all of the Department of Pathology.
Professor Antony Braithwaite
Department of Pathology, University of Otago, Tel (03) 479 7165
Can isoforms of the p53 tumour suppressor cause cancer?
36 months, $1,158,492
The Cell Transformation Group is interested in the p53 tumour suppressor protein. Research revolves around studies on how p53 works; how another cancer-related protein called YBX-1 affects p53 function; and the mechanism of YBX-1 signalling. Projects include:
- Importance of the proline domain in p53 dependent apoptosis.
- Importance of the proline domain in tumour suppression by p53.
- Role of the p53 isoforms in p53 function.
- Disease predisposition and p53.
- Interactions between Y-box binding protein (YBX-1) and p53.
- Binding partners of YBX-1.
- Investigation into BRCA-1 signalling pathway in ovarian cells.