Congratulations to Margaret Baird who has been awarded the Derrick Rowley Medal for her service to the Australasian Society for Immunology (ASI). Margaret received this award in honour of her contributions to the ASI which have included: NZ ASI councillor, ASI newsletter editor (for many years), co-founder of Immunet which provided support for the ASI NZ branch meeting and her various roles in meeting organisation (e.g. this year’s Infection and Immunity workshop).
(photograph: Susanne Heinzel)
]]>YB-1 interacting partners in breast cancer progression
Principal Investigators: Professor Antony Braithwaite (Department of Pathology, University of Otago) and Professor Boon Huat Bay (National University of Singapore).
Project summary:Y-box binding protein 1 (YB-1) is commonly elevated in many human cancers. The cancer-promoting properties of YB-1 are associated with increased resistance to drugs, tumour growth and poor patient outcome. Control of these processes takes place in the nucleus. The precise molecular nature of the active cancer-promoting subtype of YB-1 present in the nucleus is unknown. Identification of this species will provide the basis for a specific and highly prognostic indicator. This proposal, which builds on our recently published analyses of endogenous YB-1, aims to identify the molecular nature of this cancer-promoting subtype of YB-1 and to determine how it functions. From this knowledge we will develop an antibody that specifically recognises only the nuclear YB-1 species and establish this species as a prognostic indicator for human cancers.
Grant details:
Professor Antony Braithwaite
Department of Pathology, University of Otago, Tel (03) 479 7165
Can isoforms of the p53 tumour suppressor cause cancer?
36 months, $1,158,492
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